Levodopa Powder L-DOPA
What is Levodopa?
TIZAN Levodopa Powder (L-DOPA) | L-3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants. Humans, as well as a portion of the other animals that utilize L-DOPA in their biology, make it via biosynthesis from the amino acid L-tyrosine. It is the precursor to the neurotransmitters dopamine, norepinephrine, and epinephrine, which are collectively known as catecholamines.
Furthermore, Levodopa itself mediates neurotrophic factor release by the brain and CNS. It can be manufactured and in its pure form is sold as a psychoactive drug with the INN levodopa; trade names include Sinemet, Pharmacopa, Atamet, Stalevo, Madopar, and Prolopa. As a drug, it is used in the clinical treatment of Parkinson’s disease and dopamine-responsive dystonia.
It has a counterpart with opposite chirality, D-DOPA. As is true for many molecules, the human body produces only one of these isomers. The enantiomeric purity of L-DOPA may be analyzed by determination of the optical rotation or by chiral thin-layer chromatography.
It is used to replace dopamine lost in Parkinson’s disease because dopamine itself cannot cross the blood-brain barrier where its precursor can. However, L-DOPA is converted to dopamine in the periphery as well as in the CNS, so it is administered with a peripheral DDC (dopamine decarboxylase) inhibitor such as carbidopa, without which 90% is metabolised in the gut wall, and with a COMT inhibitor if possible; this prevents about a 5% loss. The form given therapeutically is therefore a prodrug which avoids decarboxylation in the stomach and periphery, can cross the blood-brain barrier, and once in the brain is converted to the neurotransmitter dopamine by the enzyme aromatic-L-amino-acid decarboxylase.
TIZAN Levodopa Powder (L-DOPA) Specifications
|L-dopa (dry basis C9H11NO4)||99.00~101.00%|
|Appearance||White to Off-White Powder|
|Solubility||Slightly soluble in water, practically insoluble in ethanol (96%), freely soluble in 1M Hydrochloric Acid and sparingly soluble in 0.1M Hydrochloric Acid.|
|Optical Rotation||-1.27°~ -1.34°|
|Absorbance||137.0 ~ 147.0|
The Best Levodopa Powder (L-DOPA) | L-3,4-dihydroxyphenylalanine Supplier TIZAN
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Why Choose TIZAN Levodopa Powder (L-DOPA) | L-3,4-dihydroxyphenylalanine?
TIZAN specialize in Levodopa Powder (L-DOPA) | L-3,4-dihydroxyphenylalanine for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.
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Store in tightly sealed containers then place in cool and dry place, and away from moisture, light, oxygen.
- Packed in paper-drums and two plastic-bags inside. N.W:25kgs .I.D.35×H51cm.
- 1Kg/Bag, aluminum foil bag vacuum packing.
- Sample, double sealed water plastic bags inside with the aluminum bag outside.