Ursolic Acid Powder
What is Ursolic Acid?
TIZAN Ursolic Acid Powder Rosemary Extract Powder (sometimes referred to as urson, prunol, malol, or 3-beta-3-hydroxy-urs-12-ene-28-oic-acid), is a pentacyclic triterpenoid identified in the epicuticular waxes of apples as early as 1920 and widely found in the peels of fruits, as well as in herbs and spices like rosemary and thyme.
A number of potential biochemical effects of ursolic acid have been investigated, but there has been no clinical study demonstrating benefits to human health. In vitro, it inhibits the proliferation of various cancer cell types by inhibiting the STAT3 activation pathway, and may also decrease proliferation of cancer cells and induce apoptosis. It has also been shown to inhibit JNK expression and IL-2 activation of JURKAT leukemic T Cells leading to the reduction in proliferation and T cell activation. It is a weak aromatase inhibitor (IC50 = 32 μM) and has been shown to increase the amount of muscle and brown fat and decrease white fat obesity and associated conditions when added to diets fed to mice. Under physiological concentrations, it also induces eryptosis (the apoptosis-like suicidal cell death in defective red blood cells). It has been found to reduce muscle atrophy and to stimulate muscular growth in mice, also shows a potential cardioprotection.
It is used as a cosmetics additive. It can serve as a starting material for synthesis of more potent bioactive derivatives, such as experimental antitumor agents.
What is Rosemary Extract?
Rosemary extract is a series natural plant extracts which extracted from Rosmarinus officinalis L, also named rosemary leaf extract. Applied to the skin, rosemary essential oil helps strengthen the capillaries and has a rejuvenating effect. Recent research is now revealing even more benefits attached to this remarkable herb, including its ability to help prevent cancer and age-related skin damage, boost the functioning of the liver and act as a mild diuretic to help reduce swelling. Although rosemary extract has been used commercially as an antimicrobial food preservative for years, now we know for certain that it also has a lot to offer as a nutritional supplement, 1 especially in the prevention of some types of cancer, allergies, and the progression of Alzheimer’s disease.
Rosmarinic acid exhibits various pharmacological activities including prevention of oxidation of low density lipoprotein, inhibition of murine cell proliferative activity and of cyclooxygenase, and anti-allergic action.
Ursolic aicd has wide biological effect and antioxidant effect, which act positively in anti-aging and removing splash. It can prevent and improve wrinkle and old-age splash through restore the skin’s collagen bundle construction and elastic. As a kind of cosmetics, it’s steady, its color and odor won’t change with the time. In addition, it has a good sense of touch.
Carnosic acid has outstanding fat-solubility, which can be used as antioxidant in meat, dairy products, oily-rich products, sweets.
Carnosol is a major component of Rosmarinus officinalis, it is a phenolic diterpene that has potent antioxidant and anti-inflammatory activities.
Rosemary Extract Benefits
- Provides powerful antioxidant protection.
- Protects brain cells from the normal effects of aging.
- May slow down the progression of Alzheimer’s disease.
- Protects cells from carcinogens.
- Inhibits growth of cancer cells.
- Helps reduce allergy symptoms, especially to dust mites.
- Increases potency of vitamin E.
- Helps reduce hypertension.
Ursolic Acid Benefits
It is well known to possess a wide range of biological functions, such as antioxidative, anti-inflammatory, antihyperlipidemic and anticancer activities, that are able to counteract endogenous and exogenous biological stimuli.
It was shown to stimulate muscle growth, provide a cardioprotective effect, and reduce the risk of obesity.
Ursolic acid is effective in protecting against chemically induced liver injury in laboratory animals. The mechanism of hepatoprotection by these two compounds may involve the inhibition of toxicant activation and the enhancement of the body defense systems.
Ursolic acid has been noted for their antitumor-promotion activities. Ursolic acid is capable of inducing apoptosis in tumor cells on one side and to prevent malignant transformation of normal cells on the other side. It also interferes with numerous enzymes, including the ones serving directly to DNA synthesis.
Ursolic acid induced apoptosis via inhibition of NF-kappaB induced bcl-2 mediated anti-apoptotic pathway and subsequent activation of p53 mediated and TNF-alpha induced caspase-3 mediated pro-apoptotic pathways in a study of B16F-10 melanoma cells.
In contrast to these beneficial properties, some laboratory studies have recently revealed that the side effects of ursolic acid on normal cells and tissues are occasionally pro-inflammatory. Otherwise, ursolic acid is relatively non-toxic, and has been used in cosmetics and health products.
Ursolic Acid Side Effects
It has an extremely low rate of intestinal absorption. A bioavailability of 0.6% has been reported when taken orally. This means that a lot of this substance needs to be consumed to have an effect. Mice supplemented with Ursolic Acid have shown infertility due to damage to, and fusion of sperm precursor cells. Reduced sperm motility has also been observed. In addition, there is some concern that Ursolic acid, when administered at effective doses, can cause DNA damage. This is thought to be one of the mechanisms behind the anti-tumour properties of this substance, but the same effects have been observed on healthy cells. Fnally, and importantly, there is no information on the effects in humans. Whilst in vitro experiments and trials in mice have shown promise, there is no way to predict effects in without testing this directly.
Ursolic Acid Powder Rosemary Extract Powder Specification
|Latin Name||Rosmarinus officinalis L.|
|Part of Used||Leaf|
|Active Ingredients||Ursolic Acid|
|Specification Available||Ursolic Acid 5%, 10%,15%, 20%,25%,30%, 50%, 90% HPLC|
|Appearance||Yellow Greenish to Light Yellow Powder or White Powder|
The Best Rosemary Extract Ursolic Acid Powder Supplier
Tizan enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in ursolic acid powder rosemary extract powder, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time. Rosemary extract is our specialty.
We also focus on value-added services. We are available for service questions and information to support your business.
Why Choose TIZAN Ursolic Acid Powder Rosemary Extract Powder?
Tizan specialize in ursolic acid powder rosemary extract powder for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.
Where to buy Ursolic Acid Powder Rosemary Extract Powder?
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Store in tightly sealed containers in cool and dry place, away from moisture, light, oxygen.
- Packed in paper-drums and two plastic-bags inside. N.W:25kgs .I.D.35×H51cm.
- 1Kg/Bag, aluminum foil bag vacuum packing.
- Sample, double sealed water plastic bags inside with the aluminum bag outside.